Publikationen

Sehr geehrte Interessenten,

Die Mitarbeiter der Sektion beteiligen sich an wissenschaftlichen Arbeiten, die veröffentlicht werden, und als Rezensenten / Gutachter zu wissenschaftlichen Publikationen anderer.
Bitte finden Sie unten eine Auswahl eigener wissenschaftlicher Publikationen aus der Sektion.

2020 - 2021

Winzinger EP, Jandikova H, Haase M, Knauerhase A, Winzinger T, Schott M, Willenberg HS. DHEAS and differential blood counts as indirect signs of glucocorticoid excess in adrenal non-producing adenomas. Horm Metab Res 2021. In Press.

Rossi GP, Crimì F, Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J, Naruse M, Deinum J, Schultze Kool L, Kocjan T, Negro A, Rossi E, Kline G, Tanabe A, Satoh F, Rump LC, Vonend O, Willenberg HS, Fuller PJ, Yang J, Chee NYN, Magill SB, Shafigullina Z, Quinkler M, Oliveras A, Wu VC, Kratka Z, Barbiero G, Seccia TM, Battistel M. Identification of Surgically Curable Primary Aldosteronism by Imaging in a Large Multiethnic International Study. J Clin Endocrinol Metab 2021. Online.

Philipp M, Reichenbach K, Klar B, Heuschkel M, Krause BJ, Schafmayer C, Willenberg HS. Diagnostik & Therapie von Erkrankungen der Nebenschilddrüse – der primäre Hyperparathyreoidsmus. Ärzteblatt MV 2021;5:165-170.

Verburg FA, Amthauer H, Binse I, Brink I, Buck A, Darr A, Dierks C, Koch C, König U, Kreissl MC, Luster M, Reuter C, Scheidhauer K, Willenberg HS, Zielke A, Schott M. Questions and Controversies in the Clinical Application of Tyrosine Kinase Inhibitors to Treat Patients with Radioiodine-Refractory Differentiated Thyroid Carcinoma: Expert Perspectives. Horm Metab Res 2021;53:149–160.

Rossi GP, Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J Jr, Mitsuhide N, Deinum J, Schultzekool L, Kocjan T, Negro A, Rossi E, Kline G, Tanabe A, Satoh F, Rump LC, Vonend O, Willenberg HS, Fuller P, Yang J, Chee NYN, Magill SB, Shafigullina Z, Quinkler M, Oliveras A, Lee BC, Wu VC, Somloova Z, Maiolino G, Seccia TM, Lenzini L. Drug-Resistant Hypertension in Primary Aldosteronism Patients Undergoing Adrenal Vein Sampling: The AVIS-2-RH Study. Eur J Prev Cardiol 2021. Online.

Friedrich F, Mueller K, Bruch PG, Hakenberg OW, Bastian M, Almansor S, Willenberg HS. Flow-dependent differentiation of cultured adrenal cells under different stimuli. Cell Tissue Res 2021;384:325–331.

Hoeflich A, Fitzner B, Walz C, Hecker M, Tuchscherer A, Bastian M, Brenmoehl J, Schröder I, Willenberg HS, Reincke M, Zettl UK. Systemic effects by intrathecal administration of triamcinolone acetonide in patients with multiple sclerosis. Front Endocrinol 2020;11:574.

Kanaan E, Haase M, Vonend O, Reincke M, Schott M, Willenberg HS. Aldosterone-mediated sodium retention is reflected by the serum sodium to urinary sodium to (serum potassium)2 to urinary potassium (SUSPPUP) index. Diagnostics 2020;10:545-555.

Sondermann M, Holecki M, Kirsch AM, Bastian M, Fischer DC, Willenberg HS. Diabetes mellitus and hypertension – a case of sugar and salt? Int J Mol Sci 2020;21:5200-5207.

Philipp M, Reichenbach K, Plath R, Schwarzenböck S, Krause BJ, Schafmayer C, Willenberg HS. Aktuelle Diagnostik und minimalinvasive Therapie von Tumoren der Nebenniere – Bericht aus einem Zentrum. Ärzteblatt MV 2020; 8:265-270.

Burger-Stritt S, Eff A, Quinkler M, Kienitz T, Stamm B, Willenberg HS, Meyer G, Klein J, Reisch N, Droste M, Hahner S. Standardised patient education in adrenal insufficiency: a prospective multi-centre evaluation. Eur J Endocrinol 2020;183:119-127.

Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J, Mitsuhide N, Deinum J, Schultzekool L, Kocjan T, Negro A, Rossi E, Kline G, Tanabe A, Satoh F, Rump LC, Vonend O, Willenberg HS, Fuller P, Yang J, Chee NYN, Magill SB, Shafigullina Z, Quinkler M, Oliveras A, Chang CC, Wu VC, Somloova Z, Maiolino G, Barbiero G, Battistel M, Lenzini L, Quaia E, Pessina AC, Rossi GP. Subtyping of Primary Aldosteronism in the AVIS-2 Study: Assessment of Selectivity and Lateralization. J Clin Endocrinol Metab 2020;105:dgz017.

2018 - 2019

Kleinschmidt HG, Seifert-Klauss V, Willenberg HS. Hyperandrogenämie: adrenal oder ovariell? In: Syllabus – Intensivkurs für Klinische Endokrinologie & Diabetologie 2019;128-135.

Rossi GP, Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J Jr, Naruse M, Deinum J, Schultze Kool L, Kocjan T, Negro A, Rossi E, Kline G, Tanabe A, Satoh F, Christian Rump L, Vonend O, Willenberg HS, Fuller PJ, Yang J, Chee NYN, Magill SB, Shafigullina Z, Quinkler M, Oliveras A, Dun Wu K, Wu VC, Kratka Z, Barbiero G, Battistel M, Chang CC, Vanderriele PE, Pessina AC. Clinical Outcomes of 1625 Patients With Primary Aldosteronism Subtyped With Adrenal Vein Sampling. Hypertension 2019;74:800-808.

Sondermann M, Willenberg HS. Nichtinsuline bei Diabetes mellitus Typ 1. Kompendium Diabetes 2019;14:17–24.

Backman S, Åkerström T, Maharjan R, Cupisti K, Willenberg HS, Hellman P, Björklund P. RNA sequencing provides novel insights into the transcriptome of aldosterone producing adenomas. Sci Rep 2019;9:6269.

Berlin P, Reiner J, Wobar J, Bannert K, Glass Ä, Walter M, Bastian M, Willenberg HS, Vollmar B, Klar E, Seidler U, Lamprecht G, Witte M. Villus growth, increased intestinal epithelial sodium selectivity, and hyperaldosteronism are mechanisms of adaptation in a murine model of short bowel syndrome. Dig Dis Sci 2019; 64:1158–1170 .

Molinnus D, Hardt G, Käver L, Willenberg HS, Kröger JC, Poghossian A, Keusgen M, Schöning MJ. Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling. Sens Actuators B Chem 2018;272:21–27.

Willenberg HS, Kupfer SE. Rational Screening in Adrenal Tumors. Dtsch Med Wochenschr 2018;143:1227-1234.

Kupfer SE, Willenberg HS. Diagnostik und Therapie des primären Hyperaldosteronismus. In: Syllabus – Intensivkurs für Klinische Endokrinologie & Diabetologie 2018;111-118.

Molinnus D, Hardt G, Siegert P, Willenberg HS, Poghossian A, Keusgen M, Schöning MJ. Detection of adrenaline in blood as biomarker for adrenal venous sampling. Electroanalysis 2018;30:937–942.

Klar B, Jacoby U, Emmert S, Willenberg HS. Ausgeprägte Hypothyreose bei einem 18-jährigen Patienten mit Morbus Basedow nach einer Thyreoiditis syphilitica. S.237-243. Schilddrüse 2017 / Thyreologie – interdisziplinär! Goretzki P (Ed.), lehmanns Media

Willenberg HS, Knauerhase A. (Neuro)endokrinologische Veränderungen im Rahmen des SHT. S. 373-381. Handbuch Schädel-Hirn-Trauma; Rickels & Piek (Eds.), de Gruyter, 2018.

Heinrich DA, Adolf C, Rump LC, Quack I, Quinkler M, Hahner S, Januszewicz A, Seufert J, Willenberg HS, Nirschl N, Sturm L, Beuschlein F, Reincke M. Primary aldosteronism: key characteristics at diagnosis: a trend toward milder forms.Eur J Endocrinol 2018;178:605–611.

Löser A, Schwarzenböck SM, Heuschkel M, Willenberg HS, Krause BJ, Kurth J. Peptide receptor radionuclide therapy with 177Lu-DOTA-octreotate: dosimetry, nephrotoxicity, and the effect of hematological toxicity on survival. Nucl Med Commun 2018;39:236–246.

Laufs V, Altieri B, Sbiera S, Kircher S, Steinhauer S, Beuschlein F, Quinkler M, Willenberg HS, Rosenwald A, Fassnacht M, Ronchi CL. ERCC1 as predictive biomarker to platinum-based chemotherapy in adrenocortical carcinomas. Eur J Endocrinol 2018;178:183–190.

2016 - 2017

Molinnus D, Hardt G, Käver L, Willenberg HS, Poghossian A, Keusgen M, Schöning MJ. Detection of adrenaline based on bioelectrical system tu support tumor diagnostic technology. MDPI Proceedings 2017;1:506.

Haase M, Dringenberg T, Allelein S, Willenberg HS, Schott M. Excessive catecholamine secretion and the activation of the Renin-Angiotensin-Aldosterone-System in patients with pheochromocytoma - A single center experience and overview of the literature. Horm Metab Res 2017;49:748–754.

Brunssen C, Hofmann A, Peitzsch M, Frenzel A, Ziegler CG, Brown NF, Weldon SM, Eisenhofer G, Willenberg HS, Bornstein SR, Morawietz H. Impact of aldosterone synthase inhibitor FAD286 on steroid hormone profile in human adrenocortical cells. Horm Metab Res 2017;49:701–706.

Williams TA, Lenders JWM, Mulatero P, Burrello J, Rottenkolber M, Adolf C, Satoh F, Amar L, Quinkler M, Deinum J, Beuschlein F, Kitamoto KK, Pham U, Morimoto R, Umakoshi H, Prejbisz A, Kocjan T, Naruse M, Stowasser M, Nishikawa T, Young WF Jr, Gomez-Sanchez CE, Funder JW, Reincke M; Primary Aldosteronism Surgery Outcome (PASO) investigators. Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort. Lancet Diabetes Endocrinol 2017;S2213-8587:30135-3.

Schröder G, Knauerhase A, Willenberg HS, Kundt G, Wendig D, Schober HC. Biomechanics of the osteoporotic spine, pain, and principles of training. Arch Orthop Trauma Surg 2017;137:617–624.

Willenberg HS. Wichtige Aspekte des Nebennierenkarzinoms. best practice onkologie 2017;1:40-49.

Willenberg HS. How to escape from primary aldosteronism? News and views on an adrenal disorder of salt retention. Horm Metab Res 2017;49:151-163.

Willenberg HS. Effect of hydrocortisone on development of shock among patients with severe sepsis. The HYPRESS Randomized Clinical Trial. Dtsch Med Wochenschr 2017;142:390-398.

Schwafertz C, Schinner C, Kühn MC, Haase M, Asmus A, Mülders-Opgenoorth B, Ansurudeen I, Hornsby PJ, Morawietz H, Bornstein SR, Oetjen E, Scherbaum WA, Schott M, Willenberg HS. Endothelial cells regulate β-catenin activity in adrenocortical cells via secretion of basic fibroblast growth factor. Mol Cell Endocrinol 2017;441:108–115.

Dringenberg T, Sorokina M, Ehlers M, Dekomien G, Haase M, Schulze E, Quinkler M, Schott M, Willenberg HS. Cloning of aldosterone synthase and CYP11B1/B2 hybrid gene fragments and assaying for familial hyperaldosteronism type 1. Horm Metab Res 2016;48:865–868.

Willenberg HS. Many channels lead to aldosterone. Commentary. EBioMedicine 2016;13:15–16.

Willenberg HS, Junghanß C. Klinisches Update zu primären Nebennierenmalignomen. J Onkol 2016;9:307–316.

Willenberg HS. Das Wichtigste zum Nebennierenrindenkarzinom. Der Onkologe 2016;22:431-446.

Knauerhase A, Willenberg HS. Novel anti-osteoporotic drugs on the horizon. Z Rheumatol 2016;75:466–470.

Åkerström T, Maharjan R, Sven Willenberg H, Cupisti K, Ip J, Moser A, Stålberg P, Robinson B, Alexander Iwen K, Dralle H, Walz MK, Lehnert H, Sidhu S, Gomez-Sanchez C, Hellman P, Björklund P. Activating mutations in CTNNB1 in aldosterone producing adenomas. Sci Rep 2016;6:19546.

Molinnus D, Sorich M, Bartz A, Siegert P, Willenberg HS, Lisdat F, Poghossian A, Keusgen M, Schöning MJ. Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate. Sens Actuators B Chem 2016;237:190–195.

Lang K, Weber K, Quinkler M,, Dietz A, Wallaschofski H, Hannemann A, Friedrich N, Rump LC, Heinze B, Quack I, Willenberg HS, Reincke M, Allolio B, Hahner S. Prevalence of neoplasms in patients with primary aldosteronism. J Clin Endocrinol Metab 2016;101:1656–1663.

Eisenhofer D, Dekkers T, Peitzsch M, Dietz AS, Bidlingmaier M, Treitl M, Williams TA, Bornstein SR, Haase M, Rump LC, Willenberg HS, Beuschlein F, Deinum J, Lenders JWM, Reincke M. Mass Spectrometry-Based Adrenal and Peripheral Venous Steroid Profiling for Subtyping Primary Aldosteronism. Clin Chem 2016;62:514–524.

Mangelis A, Dieterich P, Peitzsch M, Richter S, Juehlen R, Huebner A, Willenberg HS, Deussen A, Lenders JWM, Eisenhofer G. Computational analysis of liquid chromatography-tandem mass spectrometry steroid profiling in NCI H295R cells following angiotensin II, forskolin and abiraterone treatment. J Steroid Biochem Mol Biol 2016;155:67–75.

2014 - 2015

Beuschlein F, Weigel J, Saeger W, Kroiss M, Wild V, Daffara F, Libe R, Ardito A, Al Ghuzlan A, Quinkler M, Oßwald A, Ronchi CL, de Krijger R, Feelders RA, Waldmann J, Willenberg HS, Deutschbein T, Stell A, Reincke M, Papotti M, Baudin E, Tissier F, Haak HR, Loli P, Terzolo M, Allolio B, Müller HH, Fassnacht M. Major prognostic role of Ki67 in localized adrenocortical carcinoma after complete resection. J Clin Endocrinol Metab 2015;100:841–849.

Weigel M, Riester A, Hanslik G, Lang K, Willenberg HS, Endres S, Allolio B, Beuschlein F, Reincke M, Quinkler M. Post saline infusion test aldosterone levels indicate severity and outcome in primary aldosteronism. Eur J Endocrinol 2015;172:443–450.

Hahner S, Spinnler C, Fassnacht M, Burger-Stritt S, Lang K, Milovanovic D, Beuschlein F, Willenberg HS, Quinkler M, Allolio B. High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency - a prospective study. J Clin Endocrinol Metab 2015;100:407–416.

Weismann D, Peitzsch M, Raida A, Prejbisz A, Gosk M, Riester A, Willenberg HS, Klemm R, Manz G, Deutschbein T, Kroiss M, Därr R, Bidlingmaier M, Januszewicz A, Eisenhofer G, Fassnacht M. Measurements of plasma metanephrines by immunoassay versus LC-MS/MS for diagnosis of pheochromocytoma. Eur J Endocrinol 2015;172:251–260.

Monticone S, Satoh F, Viola A, Fischer E, Vonend O, Bernini G, Quinkler M, Ronconi V, Morimoto R, Kudo M, Degenhart C, Gao X, Willenberg HS, Riester A, Maccario M, Giacchetti G, Veglio F, Ito S, Reincke M, Mulatero P. Clinical significance of contralateral adrenal suppression during adrenal vein sampling in primary aldosteronism. J Hypertens 2015 Jun;33 Suppl 1:e120.

Thiel A, Reis AC, Haase M, Goh G, Schott M, Willenberg HS, Scholl UI. PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia – a single-center study of 60 cases. Eur J Endocrinol 2015;172:677-685.

Hanslik G, Wallaschofski H, Dietz A, Riester A, Reincke M, Allolio B, Lang K, Quack I, Rump LC, Willenberg HS, Beuschlein F, Quinkler M, Hannemann A. Increased prevalence of diabetes mellitus and the metabolic syndrome in patients with primary aldosteronism of the German Conn Registry. Eur J Endocrinol 2015;173:665–675.

Haas S, Krins S, Knauerhase A, Löhr M. Altered bone metabolism and bone density in patients with chronic pancreatitis and pancreatic exocrine insufficiency. JOP 2015;16:58-62.

Åkerström T, Willenberg HS, Cupisti K, Ip J, Backman S, Moser A, Maharjan R, Robinson B, Iwen KA, Dralle H, D Volpe C, Bäckdahl M, Botling J, Stålberg P, Westin G, Walz MK, Lehnert H, Sidhu S, Zedenius J, Björklund P, Hellman P. Novel  somatic mutations and distinct molecular signature in aldosterone-producing adenomas. Endocr Relat Cancer 2015 22:735-44.

Peitzsch M, Dekkers T, Haase M, Sweep FC, Siegert G, Lenders JW, Deinum J, Willenberg HS,  Eisenhofer G. An LC-MS/MS-based method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism. J Steroid Biochem Mol Biol 2014;145:75–84.

Blondin D, Quack I, Haase M, Kücükköylü S, Willenberg HS. Indication and technical aspects of adrenal blood sampling. RoFo 2014;187:19-28.

Haase M, Riester A, Kröpil P, Hahner S, Degenhart C, Willenberg HS, Reincke M. Outcome of adrenal vein sampling performed during concurrent mineralocorticoid receptor antagonistic therapy. J Clin Endocrinol Metab 2014;99:4397–4402.

Schöfl C, Honegger J, Droste M, Grussendorf M, Finke R, Plöckinger U, Berg C, Willenberg HS, Lammert A, Klingmüller D, Jaursch-Hancke C, Tönjes A, Schneidewind A, Flitsch J, Bullmann C, Dimopoulou C, Stalla G, Mayr B, Hoeppner W, Schopohl J. Frequency of AIP gene mutations in young patients with acromegaly: a registry-based study. J Clin Endocrinol Metab 2014;99:E2789-93.

Ehlers M, Allelein S, Haase M, Willenberg HS, Knoefel WT, Schott M. Circulating Tumor Cells in Patients with Neuroendocrine Neoplasms. Horm Metab Res 2014;46:744–745.

Schröder G, Knauerhase A, Kundt G, Schober HC. New aspects of physical therapy for osteoporosis. Osteologie 2014;23:123:132.

Goh G, Scholl UI, Healy JM, Choi M, Prasad ML, Nelson-Williams C, Kuntsman JW, Korah R, Suttorp AC, Dietrich D, Haase M, Willenberg HS, Stålberg P, Hellman P, Åkerström G, Björklund P, Carling T, Lifton RP. Recurrent activating mutation in Protein Kinase A Catalytic Subunit Alpha in cortisol-producing adrenal tumors. Nat Genet 2014;46:613–617.

Heinze B, Herrmann LJ, Fassnacht M, Ronchi CL, Willenberg HS, Quinkler M, Reisch N, Zink M, Allolio B, Hahner S. Less common genotype variants of TP53 polymorphisms are associated with poor outcome in adult patients with adrenocortical carcinoma. Eur J Endocrinol 2014:170;707–717.

Ehlers M, Thiel A, Papewalis C, Domroese A, Stenzel W, Bernecker C, Haase M, Allelein S, Schinner S, Willenberg HS, Feldkamp J, Schott M. Enhanced iodine supplementation alters the immune process in a transgenic mouse model for autoimmune thyroiditis. Thyroid 2014;24:888–896.

Werminghaus P, Haase M, Hornsby PE, Schinner S, Schott M, Lammer B, Goretzki PE, Scherbaum WA, WillenbergHS. Studies on the role of hedgehog signaling in normal human adrenal gland and adrenal tumors. J Steroid Biochem Mol Biol 2014;139:7–15.

2012 - 2013

Haase M, Willenberg HS. Hyperandrogenemia. Dtsch Med Wochenschr 2013;138:2509–2511.

Dekkers T, Deinum J, Schultzekool LJ, Blondin D, Vonend O, Hermus ARRM, Peitzsch M, Rump LC, Antoch G, Sweep FCGJ, Lenders JWM, Willenberg HS, Eisenhofer G. Plasma metanephrine for assessing the selectivity of adrenal venous sampling. Hypertension 2013;62:1152-1157.

Bernecker C, Halim F, Haase M, Willenberg HS, Ehlers M, Schott M. MicroRNA expressions in PMBCs, CD4+, and CD8+ T-cells from patients suffering from autoimmune Addison's disease. Horm Metab Res 2013;45:599-604.

Paschali M, Willenberg HS, Fritzen R, Schott M, Scherbaum WA, Schinner S. False positives on both dexamethasone testing and urinary free cortisol in women on oral contraception: dose-response effects. Clin Endocrinol 2013; 79:443-444.

Jäger F, Willenberg HS. Hormones and the critically ill. Dtsch Med Wochenschr 2013;138:697–699.

Dringenberg T, Schwitalla M, Haase  M, Scherbaum  WA, Willenberg HS. Control of CYP11B2/CYP11B1 expression ratio and consequences for the zonation of the adrenal cortex. Horm Metab Res 2013;45:81–85.

Schröder G, Knauerhase A, Kundt G, Schober HC. Effects of physical therapy on quality of life in osteoporosis patients - a randomized clinical trial. HealthQual Life Outcomes 2012;10:101.

Fourkiotis VG, Vonend O, Diederich S, Fischer E, Lang K, Endres S, Beuschlein F, Willenberg HS, Rump LC, Allolio B, Reincke M, Quinkler M. Effectiveness of Eplerenone or Spironolactone treatment in preserving renal function in primary aldosteronism. Eur J Endocrinol 2012;168:75–81.

Åkerström T, Crona J, Verdugo AD, Starker LF, Cupisti K, Willenberg HS, Knoefel WT, Saeger W, Feller F, Ip J, Soon P, Anlauf M, Alesina PF, Schmid KW, Decaussin M, Levillain P, Wängberg B, Peix JL, Robinson B, Zedenius J, Bäckdahl M, Caramuta S, Iwen KA, Botling J, Stålberg P, Kraimps JL, Dralle H, Hellman P, Sidhu S, Westin G, Lehnert H, Walz MK, Åkerström G, Carling T, Choi M, Lifton RP, Björklund P. Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS ONE 2012;7:e41926.

Gruber M, Willenberg HS, Bornstein SR.New developments in pituitary disease. Dtsch Med Wochenschr 2012;49:2540–2542.

Lachenmayer A, Cupisti K, Wolf A, Raffel A, Schott M, Willenberg HS, Eisenberger CF, Knoefel WT. Trends in adrenal surgery: Institutional review of 528 consecutive adrenalectomies. Langenbecks Arch Surg 2012;397:1099–1107.

Willenberg HS, Vonend O, Schott M, Gao X, Blondin D, Saleh A, Rump LC, Scherbaum WA. Comparison of the saline infusion test and the fludrocortisone suppression test in the diagnosis of primary aldosteronism. Horm Metab Res 2012;44:527–532.

Vogt S, Winkler E, Hermsen D, Schott M, Schinner S, Scherbaum WA, Willenberg HS. Endothelin-1 and adrenomedullin plasma levels after exposure to fludrocortisone, dexamethasone and spironolactone. Clin Exp Hypertens 2012;34:582–587.

Willenberg HS, Gruber M, Eisenhofer G, Bornstein SR.Endokrine Hypertonie – Neuigkeiten und jüngste Entwicklungen. Dtsch Med Wochenschr 2012;137:627-630.

Fassnacht M, Terzolo M, Allolio B, Baudin E, Haak H, Berruti A, Welin A, Schade-Brittinger C, Lacroix A, Jarzab B, Sorbye H, Torpy DJ, Stepan V, Schteingart DE, Arlt W, Kroiss M, Leboulleux S, Sperone P, Sundin A, Hermsen I, Hahner S, Willenberg HS, Tabarin A, Quinkler M, de la Fouchardière C, Schlumberger M, Mantero F, Weismann D, Beuschlein F, Gelderblom H, Wilmink H, Sender M, Edgerly M, R.N., M.A., Kenn W, Fojo T, Mueller HH, Skogseid B for the FIRM-ACT trial group. Combination Chemotherapy in Advanced Adrenocortical Carcinoma. N Engl J Med 2012;366:2189–2197.

2010 - 2011

Späth M, Korovkin S, Antke C, Anlauf M, Willenberg HS. Aldosterone and cortisol co-secreting adrenal tumours – the lost subtype of primary aldosteronism. Eur J Endocrinol 2011;164:447-455.

Papewalis C, Kouatchoua C, Ehlers M, Jacobs B, Porwol D, Schinner S, Willenberg HS, Anlauf M, Raffel A, Eisenhofer G, Neumann HP, Bornstein SR, Scherbaum WA, Schott M. Chromogranin A as potential target for immunotherapy of malignant pheochromocytoma. Mol Cell Endocrinol 2011;335:69–77.

Anlauf M, Gerlach P, Raffel A, Krausch M, Willenberg HS, Schmitt M, Knoefel WT, Schott M. Neuroendokrine Tumore. Classification of neuroendocrine tumors of the gastroenteropancreatic system. Klinische Onkologie 2011/2012;1–9.

Haase M, Willenberg HS, Bornstein SR. Update on the corticomedullary interaction in the adrenal gland. Endocr Dev 2011;20:28–37.

Kahl C, Jost K, Knauerhase A, Leithäuser M, Freund M, Bunke D, Rothacker D, Hampel R. Recurrent hypoglycemia and a large intraabdominal tumor in a61-year-old woman. Dtsch Med Wochenschr 2011;136:2542–2546.

Kühn MC, Willenberg HS, Schott M, Papewalis C, Stumpf U, Flohé S, Scherbaum WA, Schinner S. Adipocyte-secreted factors increase osteoblast proliferation and the OPG/RANKL ratio to influence osteoclast formation. Mol Cell Endocrinol 2011;349:180–188.

Heller C, Kühn MC, Mülders-Opgenoorth B, Schott M, Willenberg HS, Scherbaum WA, Schinner S. Exendin-4 upregulates the expression of Wnt4, a novel regulator of  pancreatic beta-cell proliferation. Am J Physiol – Endocrinol Metab 2011;301:E864-E872.

Mokosch A, Bernecker C, Willenberg HS, Neumann NJ. Kallmann syndrome. Hautarzt 2011;62:728–723.

Sbiera S, Schmull S, Assié G, Voelker HU, Kraus L, Beyer M, Ragazzon B, Beuschlein F, Willenberg HS, Hahner S, Saeger W, Bertherat J, AllolioB, Fassnacht M. High diagnostic and prognostic value of steroidogenic factor 1 in adrenal tumors. J Clin Endocr Metab 2010;95:E161–E171.

Parajes S, Loidi L, Reisch N, Dhir V, Rose IT, Hampel R, Quinkler M, ConwayGS, Castro-Feijóo L, Araujo-Vilar D, Pombo M, Dominguez F, Williams EL, Cole TR, Kirk JM, Kaminsky E, Rumsby G, Arlt W, Krone N. Functional consequences of seven novel mutations in the CYP11B1 gene: four mutations associated with nonclassicand three mutations causing classic 11{beta}-hydroxylase deficiency. J ClinEndocrinol Metab 2010;95:779–788.

Hampel R, Bennöhr G, Gordalla A, Below H. Urinary iodide excretion in adultsin germany 2005 meets WHO target. Exp Clin Endocrinol Diabetes 2010;118:254–257.

Balaş M, Zosin I, Maser-Gluth C, Hermsen D, Cupisti K, Schott M, Schinner S, Knoefel WT, Scherbaum WA, Willenberg HS. Indicators of mineralocorticoid excess in the evaluation of primary aldosteronism. Hypertens Res 2010;33:850–856.

Johanssen S, Hahner S, Saeger W, Quinkler M, Beuschlein F, Dralle H, Haaf M, Kroiss M, Jurowich C, Langer P, Oelkers W, Spahn M, Willenberg HS, Mäder U, Allolio B, Fassnacht M. Deficits in the management of patients with adrenocortical carcinoma in Germany. Dtsch Arztebl Int 2010;107:885–891.

Willenberg HS, Späth M, Maser-Gluth C, Engers R, Anlauf M, Dekomien G, Schott M, Schinner S, Cupisti K, Scherbaum WA. Sporadic solitary aldosterone- and cortisol-cosecreting adenomas – endocrine function tests, histological and genetic findings in a subtype of primary aldosteronism. Hypertens Res 2010;33:467–472.

2008 - 2009

Ziegler CG, Brown JW, Schally AV, Erler A, Gebauer L, Treszl A, Young L, Fishman LM, Engel JB, Willenberg HS, Petersenn S, Eisenhofer G, Ehrhart-Bornstein M, Bornstein SR. Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: anti-proliferative effects of peptide analogues. Proc Natl Acad Sci USA 2009;106:15879–15884.

Luckhaus C, Mahabadi B, Grass-Kapanke B, Jänner M, Willenberg H, Jäger M, Supprian T, Fehsel K. Blood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer's disease. J Neural Transm 2009;34:123–35.

Haase M, Ansurudeen I, Paramonova I, Schinner S, Schott M, Papewalis C, Scherbaum WA, Willenberg HS. Evidence for the involvement of endothelial cell products in adrenal CITED2 expression. Cell Tissue Res 2009;336:337–343.

Ansurudeen I, Willenberg HS, Kopprasch S, Ehrhart-Bornstein M, Bornstein SR. Endothelial factors mediate aldosterone release via PKA-independent pathways. Mol Cell Endocrinol 2009;300:66–70.

Schinner S, Willenberg HS, Schott M, Scherbaum WA. Pathophysiological aspects of Wnt-signalling in endocrine disease. Eur J Endocrinol 2009;160:731–737.

Willenberg HS, Kolentini C, Quinkler M, Cupisti K, Krausch M, Schott M, Scherbaum WA. The sodium to urinary sodium to (potassium)2 to urinary potassium (SUSPPUP) ratio in primary aldosteronism. Eur J Clin Invest 2009;39:43–50.

Haase M, Willenberg HS. Adrenal cortical tumors and multiple endocrine neoplasia–related syndromes. Minerva Endocrinol 2009;34:123–135.

Fassnacht M, Johanssen S, Quinkler M,  Bucsky P, Willenberg HS, Beuschlein F, Terzolo M, Mueller HH, Hahner S, Allolio B for the German ACC Registry group and the ENSAT ACC working group. Limited prognostic value of the 2004 UICC staging classification for adrenocortical carcinoma – proposal for a revised TNM classification. Cancer 2009;115:243–250.

Ramos-Lopez E, Lange B, Kahles H, Willenberg HS, Meyer G, Penna-Martinez M, Reisch N, Hahner S, Seissler J, Badenhoop K. Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II. BMC Med Genetics 2008;9:65.

Willenberg HS, Bahlo M, Wertenbruch T, M Schott, J Feldkamp, Scherbaum WA. Helpful diagnostic markers for defining hyperandrogenemia in hirsute women. Steroids 2008;73:41–46.

Willenberg HS, Schinner S, Ansurudeen I. New mechanisms to control aldosterone synthesis. Horm Metab Res 2008;40:435–441.

Willenberg HS, Lehnert H. Grundlagen und Management der Glukokortikoid-induzierten Osteoporose. Der Internist 2008;49:1186–1196.

2006 - 2007

Haase M, Schott M, Bornstein SR, Malendowicz LK, Scherbaum WA, Willenberg HS. CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor. J Endocrinol 2007;192:459–465.

Ansurudeen I, Kopprasch S, Ehrhart-Bornstein M, Bornstein SR, Willenberg HS. Endothelial cell-mediated regulation of aldosterone release from human adrenocortical cells. Mol Cell Endocrinol 2007;265–266:150–156.

Schinner S, Willenberg HS, Krause D, Schott M, Lamounier-Zepter V, Krug AW, Ehrhart-Bornstein M, Bornstein SR, Scherbaum WA. Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt signaling pathway. Int J Obes 2007;31:864–870.

Willenberg HS. Diagnostik und Therapie von Mineralokortikoidexzeßsyndromen. Roman J Endocrinol Metab 2007;2:13–23.

Willenberg HS,  Zschucke D, Bornstein SR. Adrenal tumors. DerInternist 2007;48:971–86.

Schinner S, Fritzen R, Schott M, Willenberg HS, Scherbaum WA. Spontaneous remission of primary hyperparathyroidism. Exp Clin Endocr Diab 2007;115:619–621.

Willenberg HS, Bahlo M, Schott M. Polycystic ovary syndrome and infertility. JAMA 2007;297:2582–2583.

Schott M, Sagert C, Willenberg HS, Ramp U, Varro A, Schinner S, Eisenberger C, Raffel A, Zacharowski K, Scherbaum WA, Perren A. Carcinogenic hypergastrinemia: Signet ring cell carcinoma in a patient with multiple endocrine neoplasia type 1 with Zollinger-Ellison's Syndrome. J Clin Endocrinol Metab 2007;92:3378–3382.

Papewalis C, Fassnacht M, Willenberg HS, Domberg J, Schinner S, Bornstein SR, Scherbaum WA, Schott M. Induction of antitumour immunity in adrenocortical carcinoma. Clin Endocrinol 2006;65:215–222.

Willenberg HS, Bahlo M, Scherbaum WA. Hirsutism. N Engl J Med 2006;354:1533–5.

2003 - 2005

Willenberg HS, Haase M, Papewalis C, Schott M, Scherbaum WA, Bornstein SR. Corticotropin-releasing hormone (CRH) receptor expression on normal and tumorous human adrenocortical cells. Neuroendocrinology 2005;82:274–281.

Wolf A, Willenberg HS, Cupisti K, Schott M, Geddert H, Raffel A, Bornstein SR, Scherbaum WA, Knoefel WT. Adrenal pheochromocytoma with contralateral cortisol-producing adrenal adenoma: diagnosic and therapeutic management. Horm Metab Res 2005;37:391–395.

Hampel R, Zöllner H, Glass A, Schönebeck R. No influence of urinary nitrateexcretion on the goitre prevalence in Germany. Med Klin 2003;98:547–51.

Reiners C, Schumm-Draeger PM, Geling M, Mastbaum C, Schönberger J, Laue-Savic A, Hackethal K, Hampel R, Heinken U, Kullak W, Linke R, Uhde W. Thyroid glandultrasound screening (Papillon Initiative). Report of 15 incidentally detectedthyroid cancers. Internist 2003;44:412–9.

Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, Langenbach J, Willenberg HS, Barthel A, Hauner H, McCann SM, Scherbaum WA, Bornstein SR. Human adipocytes secrete mineralocorticoid releasing factors. Proc Natl Acad Sci USA 2003;100:14211–14216.

2000 - 2002

Willenberg HS, Päth G, Vögeli TA, Scherbaum WA, Bornstein SR. Role of Interleukin-6 in the stress response in normal and tumorous adrenal cells and during chronic inflammation. Ann N Y Acad Sci2002;966:304–314.

Willenberg HS, Walters R, Bornstein SR. Use of laser microdissection in complex tissue. Methods Enzymol 2002;356:216–23.

Hampel R, Beyersdorf-Radeck B, Below H, Demuth M, Seelig K. Urinary iodinelevels within normal range in German school-age children. Med Klin 2001;96:125–128.

Maurer M, Trajanoski Z, Frey G, Hiroi N, Galon J, Willenberg HS, Gold PW, Chrousos GP, Scherbaum WA, Bornstein SR. Differential gene expression profile of glucocorticoids, testosterone, and dehydroepiandrosterone in human cells. Horm Metab Res 2001;33:691–695.

Hampel R, Gordalla A, Zöllner H, Klinke D, Demuth M. Continuous rise of urinary iodine excretion and drop in thyroid gland size among adolescents in Mecklenburg-West-Pomerania from 1993 to 1997. Exp Clin Endocrinol Diabetes 2000;108:197–201.

Willenberg HS, Bornstein SR, Hiroi N, Päth G, Goretzki PE, Scherbaum WA, Chrousos GP. Effects of a novel corticotropin-releasing-hormone receptor type 1 antagonist on human adrenal function. Mol Psych 2000;5:137–141.

1995 - 2000

Stratakis CA, Carney JA, Kirschner LS, Willenberg HS, Brauer S, Ehrhart-Bornstein M, Bornstein SR. Synaptophysin immunoreactivity in primary pigmented nodular adrenocortical disease: neuroendocrine properties of tumors associated with Carney complex. J Clin Endocrinol Metab 1999;84:1122–1128.

Willenberg HS, Hauner H, Scherbaum WA. A man with diabetes and a swollen leg. Lancet 1999;353:1527–8.

Willenberg HS, Bornstein SR, Dumser T, Ehrhart-Bornstein M, Barocka A, Chrousos GP, Scherbaum WA. Morphologic changes in adrenals from victims of suicide in relation to altered apoptosis. Endocr Res 1998;3/4:963–967.

Bornstein SR, Willenberg HS, Scherbaum WA. Progress in molecular medicine: "Laser capture microdissection". Med Klin 1998;93:739–743.

Willenberg HS, Stratakis CA, Marx C, Ehrhart-Bornstein M, Chrousos GP, Bornstein SR. Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. N Eng J Med 1998;339:27–31.

Dralle H, Gimm O, Simon D, Frank-Raue K, Görtz G, Niederle B, Wahl RA, Koch B,Walgenbach S, Hampel R, Ritter MM, Spelsberg F, Heiss A, Hinze R, Höppner W.Prophylactic thyroidectomy in 75 children and adolescents with hereditarymedullary thyroid carcinoma: German and Austrian experience. World J Surg 1998;22:744–750.

Hampel R, Gordalla A, Zöllner H, Klinke D, Demuth M. Increased dietary intakeof iodine in young people in Mecklenburg-Vorpommern 1993 and 1996. Z Ernahrungswiss 1997;36:151–154.

Hampel R, Kühlberg T, Schneider KP, Glass A, Zöllner H. Serum zinc levels and goitre epidemiology in Germany. Z Ernahrungswiss 1997;36:12–15.

Grauer A, Klar B, Knaus J, Scharla SH, Ziegler R. Bisphosphonate therapy ofPaget's disease of bone with pamidronate. Med Klin 1996;91:14–19.

Frank-Raue K, Höppner W, Frilling A, Kotzerke J, Dralle H, Haase R, Mann K, Seif F, Kirchner R, Rendl J, Deckart HF, Ritter MM, Hampel R, Klempa J, Scholz GH, Raue F. Mutations of the ret protooncogene in German multiple endocrineneoplasia families: relation between genotype and phenotype. German Medullary Thyroid Carcinoma Study Group. J Clin Endocrinol Metab 1996;81:1780–1783.